Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Our pricing system is unavailable. You are viewing list price.
Please call 1-800-766-7000 to place your order or try our site again later.

GSK3B Mouse anti-Human, Rat, Xenopus laevis, Clone: 21A, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA17621

Catalog No. 01-670-355



Description

Description

MA1-7621 detects GSK3 Beta from human, rat, and Xenopus laevis samples. MA1-7621 has been successfully used in ELISA, Western blot, immunoprecipitation and immunohistochemistry procedures. The MA1-7621 immunogen is a purified recombit Xenopus laevis protein. Store at 4°C short term. For extended storage, keep at -80°C.

Glycogen synthase kinase-3 (GSK3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3’s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C-terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, GSK3 alpha and GSK3 beta, and they are strictly regulated via phosphorylation. Phosphorylation of GSK3beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer’s disease.
Specifications

Specifications

GSK3B
Monoclonal
1 mg/mL
PBS with 0.01% sodium azide
P49841, Q9WV60, P18266, Q91757
Glycogen Synthase Kinase 3 beta, EC 2.7.11.26, GSK-3 beta, Factor A, EC 2.7.11.26, GSK-3 beta, Factor A,FA, pp37
Mouse
IgG2a
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
2932, 399097, 56637, 84027
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
21A
Unconjugated
GSK3B
Liquid
GSK3B, gsk3b.L
Purified recombit Xenopus laevis protein.
Protein G
RUO
Antibody
Monoclonal
Human, Rat, Xenopus laevis
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit