GSTM5 Mouse anti-Human, Clone: 1B3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA519027
Peptide Sequence: RPWFAGDKIT FVDFLAYDVL DMKRIFEPKC LDAFLNLKDF ISRFEGLKKI SAYMKSSQFL RGLLFGKSAT WNSKCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual ft.s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
|PBS with no preservative; pH 7.4|
|GSTM5-5, GTM5, GST class-mu 5, S-(hydroxyalkyl)glutathione lyase M5, glutathione S-alkyltransferase M5, glutathione S-aralkyltransferase M5, glutathione S-aryltransferase M5, glutathione S-transferase M5, glutathione S-transferase Mu 5|
|-20° C, Avoid Freeze/Thaw Cycles|
|GSTM5 (NP_000842, 145 a.a. ∽ 218 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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