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GSTM5 Mouse anti-Human, Clone: 1B3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA519027

Catalog No. PIMA519027


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Description

Description

Peptide Sequence: RPWFAGDKIT FVDFLAYDVL DMKRIFEPKC LDAFLNLKDF ISRFEGLKKI SAYMKSSQFL RGLLFGKSAT WNSK

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual ft.s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
Specifications

Specifications

GSTM5
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
P46439
GSTM5-5, GTM5, GST class-mu 5, S-(hydroxyalkyl)glutathione lyase M5, glutathione S-alkyltransferase M5, glutathione S-aralkyltransferase M5, glutathione S-aryltransferase M5, glutathione S-transferase M5, glutathione S-transferase Mu 5
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2949
ELISA
1B3
Unconjugated
GSTM5
Liquid
GSTM5
GSTM5 (NP_000842, 145 a.a. ∽ 218 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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