GSTM5 Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527981
PA5-27981 targets GSTM5 in WB applications and shows reactivity with mouse samples. The PA5-27981 immunogen is recombit fragment corresponding to a region within amino acids 1 and 218 of Human GSTM5. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual ft.s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
|Recombit fragment corresponding to a region within amino acids 1 and 218 of Human GSTM5|
|Antigen affinity chromatography|
|PBS with 20% glycerol and 0.01% thimerosal; pH 7|
|GSTM5-5, GTM5, GST class-mu 5, S-(hydroxyalkyl)glutathione lyase M5, glutathione S-alkyltransferase M5, glutathione S-aralkyltransferase M5, glutathione S-aryltransferase M5, glutathione S-transferase M5, glutathione S-transferase Mu 5|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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