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Granzyme B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513518

Catalog No. PIPA513518


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Description

Description

Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
Specifications

Specifications

Granzyme B
Polyclonal
Unconjugated
GZMB
Liquid
GZMB
KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human GZMB
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 0.09% sodium azide
P10144, P04187
Granzyme B; Granzyme-2; T-cell serine protease 1-3E; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; SECT; Cathepsin G-like 1; CTSGL1; CTLA-1; Fragmentin-2; Human lymphocyte protein; HLP; C11; GRB; CTLA1; CSPB; CGL1; GZMB
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14939, 3002
Documents
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