HAAO Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528035
PA5-28035 targets HAAO in WB applications and shows reactivity with Human and mouse samples. The PA5-28035 immunogen is recombit fragment corresponding to a region within amino acids 1 and 258 of Human HAAO. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
|Recombit fragment corresponding to a region within amino acids 1 and 258 of Human HAAO|
|Antigen affinity chromatography|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|3-HAO, HAO, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, HAD|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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