HAX1a Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520649
A suggested positive control is human brain tissue lysate. PA5-20649 can be used with blocking peptide PEP-0769.The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting.
|A 15 amino acid peptide near the amino terminus of human Hax1a.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|O00165, O35387, Q7TSE9|
|RP11-137P24.1, HCLSBP1, HS1BP1, SCN3; HAX-1; HCLS1 (and PKD2) associated protein; HCLS1-associated protein X-1; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|10456, 23897, 291202|
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