hCG beta Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA127113
PA1-27113 detects hCG from human samples. PA1-27113 has been successfully used in immunohistochemistry (frozen and paraffin) procedures. For staining we suggest an incubation period of 30-60 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions and antibody dilutions should be determined by the user. Although not required, proteolytic treatment may enhance the immunostaining in overfixed tissues. The PA1-27113 immunogen is beta chain of human chorionic gonadotropin.hCG beta is the beta chain of hCG (Human chorionic gonadotropin), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. hCG is made up of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those found on the pituitary hormones FSH, LH ans TSH. However, the beta subunit is different in FSH, LH and TSH and are involved in conferring biological specificity. Maintece of the fetus in the first trimester of pregcy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non-pregt urine and sera but rises sharply during pregcy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and Beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). Diseases associated with Hcg dysfunction include gestational trophoblastic tumor and hydatidiform mole, recurrent 1.
|PBS with 0.05% sodium azide; pH 7.2|
|human Chorionic gonadotrophin|
|Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|Beta chain of human chorionic gonadotropin.|
|Antigen affinity chromatography|
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