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Hck Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610278

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Catalog No. BDB610278

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The hematopoietic cell kinase (Hck), a member of the Src family of tyrosine kinases, is primarily expressed in cells of the hematopoietic system. Hck levels have been reported to increase with terminal differentiation in monocyte/macrophages and granulocytes and is further elevated during macrophage activation. Hck also has been reported to be expressed in undifferentiated embryonic stem (ES) cells. This expression is substantially reduced when ES cells are allowed to differentiate in vitro by withdrawal of leukemia inhibitory factor (LIF). Like that of other Src family tyrosine kinases, Hck activity is downregulated by phosphorylation of a conserved C-terminal tyrosine residue. This has reportedly been examined through a “hit and run” gene targeting strategy where Hck tyrosine kinase activity was elevated by replacing the Hck tyrosine 499 residue with phenylalanine. Results indicated that LIF receptor (LIFR) signaling is partially mediated by Hck. Furthermore, Hck is contained within the LIFR complex and is physically associated with gp130, the common signal transducing component of functional LIFR and IL-6 receptor complexes.

Immunofluorescence, Immunoprecipitation, Western Blotting



Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Cell Biology
Immunofluorescence, Immunoprecipitation, Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Canine, Human
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