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HDAC1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 491025

Catalog No. 49-102-5



Description

Description

Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p. HDAC1 is a class I histone deacetylase containing 482 amino acid residues. HDAC1 has been shown to interact directly with transcription factors and has been shown to deacetylate histone proteins H3 and H4.
Specifications

Specifications

HDAC1
Polyclonal
Unconjugated
HDAC1
Liquid
HDAC1
raised in rabbits against the C-terminal region of human HDAC1, using a KLH-conjugated synthetic peptide.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ChIP assay, ChIP-sequencing, ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
1.73 mg/mL
antibody with <0.1% sodium azide
Q13547, O09106
Histone deacetylase 1, HD1, HDAC1, RPD3L1
Rabbit
IgG
50 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3065, 433759
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