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HDAC11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141123

Catalog No. 01-675-705


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Description

Description

This peptide sequence is 100% homologous in multiple HDaC11 isoforms. Suggested positive control: human, mouse, or rat brain.

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). Recently, a new member of this family, HDAC11, has been cloned by Gao et al (4). HDAC11 transcripts were limited to kidney, heart, brain, skeletal muscle, and testis. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Specifications

Specifications

HDAC11
Polyclonal
Unconjugated
HDAC11
Liquid
HDAC11
Synthetic peptide corresponding to residues A(60) H Q G N G H E R D F M D D K R V Y I(78) of human HDaC11.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q96DB2, Q91WA3
FLJ22237, HD11
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
232232, 297453, 79885
Documents
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