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HDAC3 Mouse, Unlabeled, Clone: 40, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611124

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Catalog No. BDB611124


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Description

Description

Regulation of gene expression occurs at multiple levels and is mediated by numerous factors. DNA-binding proteins such as histones function to spatially organize the DNA into chromatin. The spatial organization of chromatin is also important for gene expression, and modifications to DNA-binding proteins have profound effects on gene expression. Human Histone Deacetylase 3 (HDAC3) is a protein of approximately 50kDa that removes acetyl groups from the ε-amino groups of lysines in histones, thus in competition with the acetylases. HDAC3 is the third member of this family of deacetylases, related to the yeast RPD3 gene, which affect transcription of certain human genes. HDAC3 importance is reflected in its distribution in virtually every cell type examined. In in vitro assays, HDAC3 exhibited activity towards histones H3 and H4 acetylated in vivo. Furthermore, inhibitors of deacetylation, such as sodium butyrate, inhibited HDAC3 activity. Further studies will determine the specific role of HDAC3 in regulating gene expression.

Host Species: Mouse
Clone: 40
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human HDAC3 aa. 309-425
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

HDAC3
40
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Histone Deacetylase-3
Affinity Purified
Human HDAC3 aa. 309-425
50μg
Cell Biology
Primary
Canine, Human, Murine, Rat
SDS
Documents
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