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HDAC3 Mouse, Unlabeled, Clone: 40, BD

Mouse Monoclonal Antibody

$225.00 - $405.00

Specifications

Antigen HDAC3
Isotype IgG1
Immunogen Human HDAC3 aa. 309-425
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611124
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BD Biosciences
611124
50μg Each for $225.00
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BDB611125
View Documents
BD Biosciences
611125
150μg Each for $405.00
Add to cart
 
Description

Description

Regulation of gene expression occurs at multiple levels and is mediated by numerous factors. DNA-binding proteins such as histones function to spatially organize the DNA into chromatin. The spatial organization of chromatin is also important for gene expression, and modifications to DNA-binding proteins have profound effects on gene expression. Human Histone Deacetylase 3 (HDAC3) is a protein of approximately 50kDa that removes acetyl groups from the ε-amino groups of lysines in histones, thus in competition with the acetylases. HDAC3 is the third member of this family of deacetylases, related to the yeast RPD3 gene, which affect transcription of certain human genes. HDAC3 importance is reflected in its distribution in virtually every cell type examined. In in vitro assays, HDAC3 exhibited activity towards histones H3 and H4 acetylated in vivo. Furthermore, inhibitors of deacetylation, such as sodium butyrate, inhibited HDAC3 activity. Further studies will determine the specific role of HDAC3 in regulating gene expression.

Host Species: Mouse
Clone: 40
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human HDAC3 aa. 309-425
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

HDAC3
Human HDAC3 aa. 309-425
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Histone Deacetylase-3
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
40
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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