HDAC3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA529026
PA5-29026 targets HDAC3 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-29026 immunogen is synthetic peptide corresponding to a region within amino acids 361 and 428 of Human HDAC3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
|Synthetic peptide corresponding to a region within amino acids 361 and 428 of Human HDAC3|
|Antigen affinity chromatography|
|ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|HD3, RPD3, RPD3-2, SMAP45|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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