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HDAC5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA126366

Catalog No. PIPA126366


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Description

Description

PA1-26366 detects HDAC5 from human, mouse, and rat samples. PA1-26366 has been successfully used in immunoprecipitation, immunohistochemistry (P), and Western blot procedures. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

HDAC5
Polyclonal
Unconjugated
HDAC5
Liquid
HDAC5
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
10014, 15184, 84580
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.5 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.2
Q9UQL6, Q9Z2V6
FLJ90614, HD5, NY-CO-9
Rabbit
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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