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HSP25 Rabbit anti-Guinea Pig, Hamster, Mouse, Porcine, Rat, Polyclonal, Invitrogen™ Available on GSA/VA Contract for Federal Government customers only.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA125494

Catalog No. PA125494


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Description

Description

PA1-25494 detects Heat Shock Protein 25 from mouse, rat, porcine, guinea pig, and hamster samples. PA1-25494 has been successfully used in immunoprecipitation, and Western blot procedures. The PA1-25494 immunogen is recombit mouse Heat Shock Protein 25.

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock proteins. One class of stress proteins, termed the "small heat shock proteins" is comprised of a diverse group of proteins from ~15 to >30kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated strwess protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, turmor promoter (e.g. phorbol esters) and calcium ionophores. The expression of a 24kDa protein was shown to correlate with steroid hormone receptor in cell lines, organs, and tumors. The 24kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that levels of the Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.

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Specifications

Specifications

HSP25
Polyclonal
Unconjugated
Hspb1
Liquid
HSPA1L, HSPB1
Recombit mouse Heat Shock Protein 25.
Protein A
RUO
Antibody
Polyclonal
Guinea Pig, Hamster, Mouse, Porcine, Rat
Immunoprecipitation, Western Blot
1 mg/mL
Antibody with no preservative
P14602, P16627, A5A8V7, Q5S1U1, P42930, P55063
Heat shock protein beta-1; HspB1; HSP25; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein; HSPB1; HSP27
Rabbit
IgG
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100144518, 100717481, 100724197, 100763481, 15482, 15507, 24471, 24963, 493184
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