FKBP4 Rabbit anti-Human, Mouse, Non-human primate, Rabbit, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3020
PA3-020 detects heat shock protein 56 (HSP56), also known as FKBP4/FKBP52, from human, monkey, mouse and rabbit tissues. PA3-020 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a prominent ~52 kDa band representing HSP56 HeLa cell lysate. The PA3-020 immunogen is a synthetic peptide corresponding to residues C(441) K D E R N D V A G S Q S Q V E T E A(458) of rabbit Heat Shock Protein 56. Reconstitute with PBS.Heat shock proteins (HSP) are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs including HSP70, HSP90 and HSP100. Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase ft.s, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
|Antibody with no preservative|
|Q02790, P30416, P27124|
|FKBP51; FKBP59; HBI; Hsp56; PPIase; p52; 51 kDa FK506-binding protein; 59 kDa FK506-binding protein 4; HSP binding immunophilin; T-cell FK506-binding protein; peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; rotamase|
|-20° C, Avoid Freeze/Thaw Cycles|
|100009148, 14228, 2288|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Synthetic peptide corresponding to residues C(441) K D E R N D V A G S Q S Q V E T E A(458) of rabbit Heat Shock Protein 56.|
|Antigen affinity chromatography|
|Human, Mouse, Non-human primate, Rabbit|
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