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anti-Heat Shock Protein 75/HSP75/ TRAP-1 Ab-2, Clone: TR-1A, Epredia™ LabVision
Mouse Monoclonal Antibody
Supplier: Epredia MS1309PABX
Description
A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (HSP's), more appropriately called as stress response proteins (SRP's). The Hsp90 family of proteins in mammalian cells consists of Hsp90 α and β, Grp94, and Trap-1 (Hsp75). It was found that human TRAP-1 is localized to mitochondria and exhibited ATPase activity that was inhibited by both geldanamycin and radicicol indicating that TRAP-1 has functions that are distinct from those of hsp90. It was also found that TRAP-1 had a biochemical activity to refold denatured retinoblastoma protein (Rb) into its native conformation.
Host Species: Mouse
Clone: TR-1A
Isotype: IgG2a
Cross Reactivity: Human. Others-not known.
Epitope: Not determined
Immunogen: Recombinant TRAP-1 protein
Molecular Weight: 75kDa
Positive Control: HeLa, SKBR-3 or A431 cells
Cellular Localization: cytoplasmic
Immunoprecipitation, Western Blotting
Specifications
| Heat Shock Protein 75/HSP75/ TRAP-1 Ab-2 | |
| 1mg/mL | |
| Mouse | |
| 200 μL | |
| Human | |
| IgG2a |
| Monoclonal | |
| Unconjugated | |
| Recombinant TRAP-1 protein | |
| Primary | |
| Purified |
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