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anti-Heat Shock Protein 75/HSP75/ TRAP-1 Ab-2, Clone: TR-1A, Thermo Scientific Lab Vision

Mouse Monoclonal Antibody

Specifications

Antigen Heat Shock Protein 75/HSP75/ TRAP-1 Ab-2
Format Purified
Host Species Murine
Immunogen Recombinant TRAP-1 protein
Isotype IgG2a
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Products 6
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
MS1309P
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Epredia
MS1309P
200μg/mL Unconjugated 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS1309P0
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Epredia
MS1309P0
200μg/mL Unconjugated 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS1309P1
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Epredia
MS1309P1
200μg/mL Unconjugated 500μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS1309PABX
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Epredia
MS1309PABX
1mg/mL Unconjugated 200μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS1309PCL
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Epredia
MS1309PCL
250μg/100μL Unconjugated 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS1309P1ABX
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Epredia
MS1309P1ABX
1mg/mL Unconjugated 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (HSP's), more appropriately called as stress response proteins (SRP's). The Hsp90 family of proteins in mammalian cells consists of Hsp90 α and β, Grp94, and Trap-1 (Hsp75). It was found that human TRAP-1 is localized to mitochondria and exhibited ATPase activity that was inhibited by both geldanamycin and radicicol indicating that TRAP-1 has functions that are distinct from those of hsp90. It was also found that TRAP-1 had a biochemical activity to refold denatured retinoblastoma protein (Rb) into its native conformation.

Host Species: Mouse
Clone: TR-1A
Isotype: IgG2a
Cross Reactivity: Human. Others-not known.
Epitope: Not determined
Immunogen: Recombinant TRAP-1 protein
Molecular Weight: 75kDa
Positive Control: HeLa, SKBR-3 or A431 cells
Cellular Localization: cytoplasmic

Immunoprecipitation, Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Heat Shock Protein 75/HSP75/ TRAP-1 Ab-2
Murine
IgG2a
Primary
Purified
Recombinant TRAP-1 protein
Monoclonal
SDS
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