HEF1 Mouse anti-Human, Mouse, Rat, Clone: 2G9, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA15785
This antibody detects HEF1 in human, mouse, and rat samples. This antibody does not recognize p130cas. It has not been tested on Sin1. This antibody mostly detects HEF1 localized at the focal adhesion sites.HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.
|PBS with 0.1% sodium azide|
|CAS-L, CASL, HEF1, dJ49G10.2, dJ761I2.1, CasL|
|Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|18003, 291044, 4739|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed)|
|GST-HEF-1 (82-398 aa.) from SP2/0 cells|
|Human, Mouse, Rat|
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