Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Heme Oxygenase 2 Mouse anti-Human, Unlabeled, Clone: 44, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611054

Catalog No. BDB611054

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Heme Oxygenase (HO) mediates the degradation of heme into biliverdin, free iron, and carbon monoxide (CO). HO exists as two isozymes, designated HO-1 and HO-2. These two isoforms share about 40% amino acid similarity including several stretches of highly conserved sequences with matched predicted secondary structure. HO-1, the inducible form, is found primarily in spleen and liver Kupffer cells. However, HO-2 is constitutively expressed in abundance in brain, testis, and liver parenchymal cells. Although HO-1 has an established physiological role in heme catabolism, the HO-2 mechanism is unclear. However, the HO-2 heme- inding pocket is similar to that of HO-1 and heme degradation is thought to proceed by similar mechanisms. In the brain, HO-2 colocalizes with neuronal nitric oxide synthase (nNOS) within adventitial neurons and in autonomic ganglia. Like the neurotransmitter NO, CO produced by HO-2 stimulates guanylyl cyclase Also, HO-2 may function to limit acute and chronic inflammatory responses. Thus, HO-2 serves as a mediator of heme degradation and, in doing so, may generate molecules important for neurotransmission and possibly immunomodulation.

Immunofluorescence, Western Blotting

Specifications

Specifications

Heme Oxygenase 2
44
Unconjugated
Murine
IgG2b
RUO
Primary
Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human HO-2 aa. 5-115
50μg
Cell Biology
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit