Heme Oxygenase 2 Mouse anti-Human, Unlabeled, Clone: 44, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611054
Heme Oxygenase (HO) mediates the degradation of heme into biliverdin, free iron, and carbon monoxide (CO). HO exists as two isozymes, designated HO-1 and HO-2. These two isoforms share about 40% amino acid similarity including several stretches of highly conserved sequences with matched predicted secondary structure. HO-1, the inducible form, is found primarily in spleen and liver Kupffer cells. However, HO-2 is constitutively expressed in abundance in brain, testis, and liver parenchymal cells. Although HO-1 has an established physiological role in heme catabolism, the HO-2 mechanism is unclear. However, the HO-2 heme- inding pocket is similar to that of HO-1 and heme degradation is thought to proceed by similar mechanisms. In the brain, HO-2 colocalizes with neuronal nitric oxide synthase (nNOS) within adventitial neurons and in autonomic ganglia. Like the neurotransmitter NO, CO produced by HO-2 stimulates guanylyl cyclase Also, HO-2 may function to limit acute and chronic inflammatory responses. Thus, HO-2 serves as a mediator of heme degradation and, in doing so, may generate molecules important for neurotransmission and possibly immunomodulation.
Immunofluorescence, Western Blotting
|Heme Oxygenase 2|
|Immunofluorescence, Western Blot|
|Human HO-2 aa. 5-115|
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