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MilliporeSigma™ anti-Heparin Binding Epidermal Growth Factor (Ab-1), Polyclonal

Goat Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC319L100UG

Catalog No. PC319L100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Heparin Binding Epidermal Growth Factor Clone: in Human samples, and it is validated for ELISA, Neutralization, Immuno Blotting

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a~22kDa O-glycosylated protein that is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. The natural protein has an apparent molecular mass of~19-23kDa and exists in multiple forms as a result of heterogeneous O-glycosylation and/or N-terminal truncation. HB-EGF is synthesized as a membrane-anchored precursor (proHB-EGF) that is proteolytically cleaved to release the soluble mature growth factor. The two forms are active as juxtacrine and paracrine/autocrine growth factors respectively. Recent studies show MMP-3 as one of the enzymes that cleaves HB-EGF implicating a role for MMP-3 in the regulation of HB-EGF from being a juxtacrine to a paracrine/autocrine factor. HB-EGF activates two EGF receptor subtypes, HER1/ErbB1 and HER4 and binds to heparan sulfate proteoglycan. The proHB-EGF is postulated as the high affinity receptor for diphtheria toxin (DT). Recent evidence suggests that the coexpression of proHB-EGF and CD9 on macrophages may strongly promote the development of atherosclerosis by a juxtacrine mechanism. Transcription of HB-EGF can be induced in vascular endothelial cells as well as aortic smooth muscle cells which may also play an important role in the pathogenesis of atherosclerosis.
Specifications

Specifications

Heparin Binding Epidermal Growth Factor
Unconjugated
purified
human HB-EGF
100μg
−20°C
Polyclonal
Human
ELISA, Immuno Blotting, Immunoblot, Neutralization
Lyophilized from sterile filtered solution in PBS, 5% trehalose, 100μg BSA.
Goat
IgG
RUO
Primary
Recognizes the ∽19-23kDa HB-EGF protein in vascular smooth muscle cells.
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