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TIM3 Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141295

Catalog No. 01-675-636


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Description

Description

Suggested positive control: mouse and rat kidney protein or cell lysate.

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Specifications

Specifications

TIM3
Polyclonal
Unconjugated
Havcr2
Liquid
HAVCR2
Synthetic peptide corresponding to residues 100-200 of mouse TIM-3.
Protein G
RUO
Antibody
Polyclonal
Mouse
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8VIM0
HAVCR2,TIM-3
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
171285
Documents
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