HES1 Rabbit anti-Bovine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523283
DescriptionHES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.
|whole serum with 50% glycerol and 0.025% sodium azide|
|Q3ZBG4, Q14469, P35428, Q04666|
|HES-1, HHL, HRY, bHLHb39, class B basic helix-loop-helix protein 39, hairy homolog, hairy-like protein, transcription factor HES-1|
|Bovine, Human, Mouse, Non-human primate, Rat|
|Synthetic peptide (249 TSNSGTSVGPNAVSPSSG 266) of HES1 protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
|15205, 29577, 3280, 539547|
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