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HES1 Rabbit anti-Bovine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523283

Catalog No. PIPA523283


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Description

Description

HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.
Specifications

Specifications

HES1
Polyclonal
whole serum with 50% glycerol and 0.025% sodium azide
Q3ZBG4, Q14469, P35428, Q04666
HES-1, HHL, HRY, bHLHb39, class B basic helix-loop-helix protein 39, hairy homolog, hairy-like protein, transcription factor HES-1
Rabbit
IgG
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin)
Unconjugated
HES1
Liquid
HES1
Synthetic peptide (249 TSNSGTSVGPNAVSPSSG 266) of HES1 protein.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
15205, 29577, 3280, 539547
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