HFE2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526703
This antibody is predicted to react with mouse and rat based on sequence homology.HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
|PBS with 0.09% sodium azide|
|HFE2A, HJV, JH, RGMC, RGM domain family member C, haemojuvelin, hemochromatosis type 2 protein, hemojuvelin, repulsive guidance molecule c|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2|
|Protein A, Antigen Affinity Chromatography|
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