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HFE2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA526703

Catalog No. PIPA526703


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Specifications

Specifications

HFE2
Polyclonal
PBS with 0.09% sodium azide
Q6ZVN8
HFE2A, HJV, JH, RGMC, RGM domain family member C, haemojuvelin, hemochromatosis type 2 protein, hemojuvelin, repulsive guidance molecule c
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
148738
Flow Cytometry, Western Blot
Unconjugated
HFE2
Liquid
HFE2
KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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