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HIF3A Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146117

Catalog No. PIPA146117


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Description

Description

Suggested positive control: reticulocyte lysate.

Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
Specifications

Specifications

HIF3A
Polyclonal
Unconjugated
HIF3A
Liquid
HIF3A
Bacterially expressed human HIF-3 alpha (N-terminus).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
tris citrate with 0.1% sodium azide; pH 7-8
Q9Y2N7, Q0VBL6
Hypoxia inducible factor 3a
Rabbit
IgG
100 μL
4° C, do not freeze
Primary
53417, 64344
Documents
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