HIPK3 Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523171
DescriptionHIPK3, a mammalian homolog of YAK1, is a novel 130 kDa nuclear co-factor that belongs to the HIPK protein family. Members of this family localize to nuclear speckles and consist of an evolutionarily conserved protein kinase domain and a homeoprotein-interacting domain. Physiological functions of HIPK3 have been predicted in different cell signaling pathways including transcriptional co-repression, cell differentiation, growth suppression, steroidogenesis and apoptosis. Research suggests that HIPK3 is a FADD-interacting protein kinase found to phosphorylate FADD and promote its binding to Fas, thereby inhibiting Fas-mediated Jun NH (2)-terminal kinase activation. HIPK3 also has been found to phosphorylate JNK and c-JUN, thus enhancing SF-1 activity for CYP11A1 transcription. HIPK3 plays a key role in cAMP-dependant signaling pathway.
|Synthetic peptide (875 DTDEEETSQRHSLR 888) of HIPK3 protein.|
|Antigen affinity chromatography|
|Canine, Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|Q9H422, Q9ERH7, O88850|
|RP1-8L15.1, DYRK6, FIST3, PKY, YAK1, ANPK, FIST, androgen receptor-interacting nuclear protein kinase, fas-interacting serine/threonine-protein kinase, homeodomain-interacting protein kinase 3, homolog of protein kinase YAK1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|10114, 15259, 475947, 83617|
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