HLA-DPB1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527780
PA5-27780 targets HLA-DPB1 in WB applications and shows reactivity with Human samples. The PA5-27780 immunogen is recombit protein fragment corresponding to a region within amino acids 1 and 246 of Human HLA-DPB1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
|Recombit protein fragment corresponding to a region within amino acids 1 and 246 of Human HLA-DPB1|
|Antigen affinity chromatography|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|DPB1, HLA-DP, HLA-DP1B, HLA-DPB, HLA DP14-beta chain, HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, HLA-DP histocompatibility type, beta-1 subunit, MHC HLA DPB1, MHC class II HLA-DP-beta, MHC class II HLA-DP-beta-1, MHC cla|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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