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HLA-DQB1, Mouse, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a full-length human HLA-DQB1 protein.

Manufacturer:  Abnova Corporation H00003119B01

Catalog No. 89-005-537


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Description

Description

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq

Sequence: MSWKKALRIPGGLRVATVTLMLAMLSTPVAEGRDSPEDFVYQFKGMCYFTNGTERVRLVTRYIYNREEYARFDSDVGVYRAVTPLGPPAAEYWNSQKEVLERTRAELDTVCRHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETTGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQNPIIVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGLLH
Specifications

Specifications

HLA-DQB1
Unconjugated
No additive
BC012106
CELIAC1|HLA-DQB|IDDM1
Mouse
50 uL
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Primary
3119
Flow Cytometry, Western Blot
Mouse polyclonal antibody raised against a full-length human HLA-DQB1 protein.
HLA-DQB1
Serum
HLA-DQB1
HLA-DQB1 (AAH12106, 1 a.a. ~ 261 a.a) full-length human protein.
RUO
Y
Polyclonal
Human
Documents
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