HLA-DR Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522279
PA5-22279 targets HLA-DR in WB applications and shows reactivity with Human samples. The PA5-22279 immunogen is recombit protein fragment contain a sequence corresponding to a region within amino acids 56 and 250 (P01911) of HLA-DRB1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
|Recombit protein fragment contain a sequence corresponding to a region within amino acids 56 and 250 (P01911) of HLA-DRB1|
|Antigen affinity chromatography|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|XXbac-BPG161M6.1, DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, DW2.2/DR2.2, HLA class II histocompatibility antigen, DR-1 beta chain, MHC class II HLA-DR beta 1 chain, MHC class II HLA-DR-beta cell surface glycoprotein, MHC class II HLA-DRw10-beta, MHC class II antigen, human leucocyte antigen DRB1, lymphocyte antigen DRB1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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