HLA-G, Mouse, Clone: 2A12, Abnova
Mouse monoclonal antibody raised against synthetic peptide of HLA-G.
Manufacturer: Abnova Corporation MAB0966
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
|The optimal working dilution should be determined by the end user.|
|Flow Cytometry, Immunohistochemistry, Western Blot|
|Mouse monoclonal antibody raised against synthetic peptide of HLA-G.|
|In PBS, pH 7.4 (0.09% sodium azide)|
|A synthetic peptide (conjugated with OVA) corresponding to C-terminus of human soluble HLA-G5 and HLA-G6.|
|Store at 4°C|
|This antibody allows to discriminate between soluble HLA-G protein yielded by shedding from membrane-bound HLA-G forms that do not contain the intron 4-encoded epitope and soluble HLA-G5/HLA-G6 produced from intron 4-retaining alternatively spliced mRNAs.|
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