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HMGA1 Rabbit anti-Canine, Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141326

Catalog No. 01-675-663


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Description

Description

This antibody is predicted to react with chicken and bovine samples based on sequence homology. Suggested positive control: human pancreas protein, antigen standard for HMGA1 (transient overexpression lysate), pancreas lysate.

Principal Names: High Mobility Group AT-Hook 1 (HMGA-1); High mobility group protein HMG-I/HMG-Y, HMG-I(Y); HMG-R; Official Gene Symbol: HMGA1 HMGA1, an 11KDa basic, DNA-binding non-histone nuclear protein, is a key member of HMGA protein family. It consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. It also physically interacts with transcription factors such as AP-1, Sp-1 and CAAT/enhancer binding protein-beta to modulate their ability to activate gene expression. It functions as a direct transcriptional target of c-Jun and c-Myc and is maximally expressed during embryonic development. Pathological role of HMGA1 include integration of retroviruses into chromosomes and enhancing metastasis of tumor cells.
Specifications

Specifications

HMGA1
Polyclonal
Unconjugated
HMGA1
Liquid
HMGA1
Synthetic peptide corresponding to amino acids 19-32 of human HMGa1.
Affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Porcine, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q6URC2, P17096, P17095, Q8K585
HMGA1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100157848, 117062, 15361, 3159, 442946
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