HMGA1 Rabbit anti-Canine, Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141326
This antibody is predicted to react with chicken and bovine samples based on sequence homology. Suggested positive control: human pancreas protein, antigen standard for HMGA1 (transient overexpression lysate), pancreas lysate.Principal Names: High Mobility Group AT-Hook 1 (HMGA-1); High mobility group protein HMG-I/HMG-Y, HMG-I(Y); HMG-R; Official Gene Symbol: HMGA1 HMGA1, an 11KDa basic, DNA-binding non-histone nuclear protein, is a key member of HMGA protein family. It consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. It also physically interacts with transcription factors such as AP-1, Sp-1 and CAAT/enhancer binding protein-beta to modulate their ability to activate gene expression. It functions as a direct transcriptional target of c-Jun and c-Myc and is maximally expressed during embryonic development. Pathological role of HMGA1 include integration of retroviruses into chromosomes and enhancing metastasis of tumor cells.
|Synthetic peptide corresponding to amino acids 19-32 of human HMGa1.|
|Canine, Human, Mouse, Porcine, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q6URC2, P17096, P17095, Q8K585|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100157848, 117062, 15361, 3159, 442946|
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