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HRK Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA186773

Catalog No. PIPA186773


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Description

Description

In Western blot, this antibody detects a band at ~13 kDa in mouse pancreas tissue lysate. Rabbit anti HRK antibody detects Harakiri (HRK), also known as Neuronal death protein DP5 or BH3-interacting domain-containing protein 3. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis.

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.
Specifications

Specifications

HRK
Polyclonal
Unconjugated
HRK
Liquid
HRK
15 amino acid peptide from near the centre of human HRK
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O00198, P62816, P62817
DP5, HARAKIRI
Rabbit
IgG
100 μg
4°C or -20°C if preferred
Primary
117271, 12123, 8739
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