Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

HRK Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520235

Catalog No. PIPA520235


Add to cart

Description

Description

Despite its predicted molecular weight, Hrk often migrates at 12-15kDa in SDS-PAGE. A suggested positive control is mouse pancreas tissue lysate. PA5-20235 can be used with blocking peptide PEP-0369.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
Specifications

Specifications

Hrk
Polyclonal
Unconjugated
HRK
Liquid
HRK
A 15 amino acid peptide from near the center of human Hrk.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O00198, P62816
DP5, HARAKIRI; BCL2-interacting protein; BH3-interacting domain-containing protein 3; activator of apoptosis Hrk; activator of apoptosis harakiri; death protein 5; neuronal death protein DP5
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
12123, 8739
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit