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HSD11B2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA526767

Catalog No. PIPA526767


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Description

Description

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Specifications

Specifications

HSD11B2
Polyclonal
PBS with 0.09% sodium azide
P80365
AME, AME1, HSD11K, HSD2, SDR9C3, -HSD11 type II, 11-DH2, 11-beta-HSD, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type 2, 11-beta-hydroxysteroid dehydrogenase type II, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 2, short chain dehydroge
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3291
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
HSD11B2
Liquid
HSD11B2
KLH conjugated synthetic peptide between 277-306 amino acids from the central region of human HSD11B2
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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