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BABAM1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA526014

Catalog No. PIPA526014


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Description

Description

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes  ft.Lys-63 ft.-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes  ft.Lys-63 ft.-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves  ft.Lys-63 ft.-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the  ft.Lys-63 ft.-linked deubiquitinase activity mediated by BRCC3/BRCC36.
Specifications

Specifications

BABAM1
Polyclonal
PBS with 0.09% sodium azide
Q9NWV8
C19orf62, MERIT40, NBA1, BRCA1-A complex subunit MERIT40, BRISC and BRCA1-A complex member 1, mediator of RAP80 interactions and targeting subunit of 40 kDa, mediator of Rap80 interactions and targeting 40 kDa, new component of the BRCA1 A complex, new component of the BRCA1-A complex
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29086
Immunohistochemistry, Western Blot
Unconjugated
BABAM1
Liquid
BABAM1
KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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