BABAM1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA526014

Catalog No. PIPA526014

Description

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36.

Specifications

• Antigen: BABAM1
• Classification: Polyclonal
• Gene: BABAM1
• Gene Alias: C19orf62, MERIT40, NBA1, BRCA1-A complex subunit MERIT40, BRISC and BRCA1-A complex member 1, mediator of RAP80 interactions and targeting subunit of 40 kDa, mediator of Rap80 interactions and targeting 40 kDa, new component of the BRCA1 A complex, new component of the BRCA1-A complex
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29086
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q9NWV8
• Gene Symbols: BABAM1
• Immunogen: KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG