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BABAM1 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA526014
Description
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36.Specifications
BABAM1 | |
Polyclonal | |
BABAM1 | |
C19orf62, MERIT40, NBA1, BRCA1-A complex subunit MERIT40, BRISC and BRCA1-A complex member 1, mediator of RAP80 interactions and targeting subunit of 40 kDa, mediator of Rap80 interactions and targeting 40 kDa, new component of the BRCA1 A complex, new component of the BRCA1-A complex | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
29086 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry, Western Blot | |
Unconjugated | |
Q9NWV8 | |
BABAM1 | |
KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142 | |
400 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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