HTRA1 Rabbit anti-Bovine, Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523395
DescriptionHtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregcy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
|whole serum with 50% glycerol and 0.025% sodium azide|
|F1N152, Q92743, Q9R118, Q9QZK5|
|ARMD7, HtrA, L56, ORF480, PRSS11, IGFBP5-protease, high-temperature requirement A serine peptidase 1, protease, serine, 11 (IGF binding), serine protease HTRA1|
|Bovine, Canine, Human, Mouse, Non-human primate, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Synthetic peptide (aa 234-249; NGATYEAKIKDVDEKA) of HtrA1 protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
|282326, 477852, 56213, 5654, 65164|
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