Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

HTRA1 Rabbit anti-Bovine, Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523395

Catalog No. PIPA523395


Add to cart

Description

Description

HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregcy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
Specifications

Specifications

HtrA1
Polyclonal
whole serum with 50% glycerol and 0.025% sodium azide
F1N152, Q92743, Q9R118, Q9QZK5
ARMD7, HtrA, L56, ORF480, PRSS11, IGFBP5-protease, high-temperature requirement A serine peptidase 1, protease, serine, 11 (IGF binding), serine protease HTRA1
Rabbit
IgG
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Mouse, Non-human primate, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
HTRA1
Liquid
HTRA1
Synthetic peptide (aa 234-249; NGATYEAKIKDVDEKA) of HtrA1 protein.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
282326, 477852, 56213, 5654, 65164
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit