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HTRA2 Mouse anti-Human, Clone: 196C429, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141040

Catalog No. 01-676-449


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Description

Description

Suggested positive control: HL-60 or Jurkat whole cell lysate.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
Specifications

Specifications

HtrA2
Monoclonal
Unconjugated
HTRA2
Liquid
HTRA2
Synthetic peptide corresponding to residues 335-350 of human Htra2.
Protein G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
196C429
PBS with 0.05% BSA and 0.05% sodium azide
O43464
Omi
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
27429
Documents
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