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IκBα Mouse anti-Human, Unlabeled, Clone: 25, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610691

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Catalog No. BDB610691


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Description

Description

NF-κB is a transcription factor that regulates many cytokine and Ig genes involved in immune response, inflammation, and viral infections. NF-κB is induced by cytokines and lipopolysaccharide (LPS), but is inhibited by glucocorticoids. IκBα/MAD-3 inhibits the DNA-binding activity of NF-κB and related transcription factors. In THP-1 monocytic-like cells, LPS induces the phosphorylation and inactivation of IκBα, which results in the activation of NF-κB. Therefore, phosphorylation of IκBα may induce the dissociation of the IκBα/NF-κB complex.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

IκBα
25
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
MAD-3; I-kappa-B-alpha; IkB-alpha; NFKBIA; NF-kappa-B inhibitor alpha
Affinity Purified
Human IκBα aa. 145-302
150μg
Cell Biology
Primary
Human
Documents
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