NF-κB is a transcription factor that regulates many cytokine and Ig genes involved in immune response, inflammation, and viral infections. NF-κB is induced by cytokines and lipopolysaccharide (LPS), but is inhibited by glucocorticoids. IκBα/MAD-3 inhibits the DNA-binding activity of NF-κB and related transcription factors. In THP-1 monocytic-like cells, LPS induces the phosphorylation and inactivation of IκBα, which results in the activation of NF-κB. Therefore, phosphorylation of IκBα may induce the dissociation of the IκBα/NF-κB complex.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Human IκBα aa. 145-302|
|MAD-3; I-kappa-B-alpha; IkB-alpha; NFKBIA; NF-kappa-B inhibitor alpha|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
For Research Use Only.
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