anti-I-kappa-B-alpha Clone: 6H7L22, Invitrogen™
I-kappa-B-alpha Monoclonal antibody 701098 from Thermo Scientific™ Pierce™ specifically detects I-kappa-B-alpha in Human samples, and it is validated for WB
Manufacturer: Invitrogen 701098
I kappa B-alpha is a 40 kDa protein that functions to inhibit NF- kappaB activity. The inhibition occurs via protein-protein interaction between I kappaB proteins and NF- kappaB dimers in the cytosol. The interaction of I kappa B-alpha with NF- kappaB masks the nuclear localization sequence of NF- kappaB, preventing NF- kappaB translocation to the nucleus. A variety of stimuli can activate gene expression by liberating NF- kappaB through the degradation of I kappaB alpha. These stimuli include the proinflammatory cytokines TNF- alpha and IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, as well as various chemical and physical stresses. In humans, the gene is located on the q arm of chromosome 14.
701098 detects I-kappa-B-alpha in Human samples. 701098 has been successfully used in WB procedures. The immunogen for 701098 is recombinant protein corresponding to amino acids 1-110 of human NF-kappa-B inhibitor alpha.
|Store at 2 to 8°C for up to 1 month. For long term storage, store at -20°C.|
|100μg of Protein A antibody in PBS with 0.09% sodium azide;|
|Recombinant protein corresponding to amino acids 1-110 of human NF-kappa-B inhibitor alpha|
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