IRF8 Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19055
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
|Synthetic peptide corresponding to the C terminus amino acids QRSFFRENQQITV.|
|Antigen affinity chromatography|
|Immunohistochemistry, peptide-ELISA, Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|ICSBP1; interferon consensus sequence binding protein 1; IRF8; IRF-8; H-ICSBP; interferon regulatory factor 8|
|-20° C, Avoid Freeze/Thaw Cycles|
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