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IRF8 Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19055

Catalog No. 01-674-639


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Description

Description

This antibody is predicted to react with bovine, mouse and rat based on sequence homology.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Specifications

Specifications

IRF8
Polyclonal
Unconjugated
IRF8
Liquid
IRF8
Synthetic peptide corresponding to the C terminus amino acids QRSFFRENQQITV.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q02556
ICSBP1; interferon consensus sequence binding protein 1; IRF8; IRF-8; H-ICSBP; interferon regulatory factor 8
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3394
Documents
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