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IEX-1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520391

Catalog No. PIPA520391


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20391 can be used with blocking peptide PEP-0508.

IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappa-B/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.
Specifications

Specifications

IEX-1
Polyclonal
Unconjugated
IER3
Liquid
IER3
A 24 amino acid peptide near the center of human IEX1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P46695, P46694
DADB-118P11.5, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1; PACAP-responsive gene 1 protein; anti-death protein; differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; gly96, mouse, homolog of; immediate early protein GLY96; immediate early response 3 protein; immediately early gene X-1; protein DIF-2; radiation-inducible immediate-early gene IEX-1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
15937, 8870
Documents
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