IFN-Gamma Mouse anti-Human, BUV395, Clone: B27, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563563
The B27 monoclonal antibody specifically binds to human interferon-γ (IFN-γ). IFN-γ is a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ+ T cells. IFN-γexerts its biological effects through specific binding to the high-affinity IFN-γ Receptor Complex comprised of IFN-γβ subunits. In addition to its antiviral effects, IFN-γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils. In addition, IFN-γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of B cell and T cell subsets. These influences can involve IFN-γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells themselves. Human IFN-γis a 14-18 kDa glycoprotein containing 143 amino acid residues. B27 is a neutralizing antibody. The use of B27 antibody for epitope mapping of human IFN-γ has been described. The B27 antibody has been reported not to bind to denatured IFN-γ.
|IFNG; Interferon-gamma; Interferon-γ; Type II interferon; MAF|
|Human IFN-Gamma Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Brilliant Ultraviolet 395|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
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