MilliporeSigma™ anti-IGF-I Alexa Fluor 488, Clone: Sm1.2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ 05172AF488

Catalog No. 05-172-AF488

Description

Specifically detects IGF-I Clone: Sm1.2 in Chicken, Fish, Human, Mouse, Rat samples, and it is validated for Immunocytochemistry

Insulin-like growth factor I (UniProt P05019; also known as IGF-I, Somatomedin-C) is encoded by the IGF1 (also known as IGFI, MGF) gene (Gene ID 3479) in human. Human insulin-like growth factor-I (IGF-I) is a single chain 70 amino acid polypeptide that shares structural homology with insulin and human IGF-II. IGF-I plays a critical role in growth, differentiation and development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-I is a regulator of metabolism and is also implicated in the pathophysiology of cancer, diabetes and obesity. Upon binding the tetrameric (alpha:beta)2 IGF-I receptor, the receptor alpha chains induce the tyrosine autophosphorylation of the beta chains, which in turn trigger cell type-specific downstream signaling cascade of events.

Specifications

• Antigen: IGF-I
• Classification: Monoclonal
• Conjugate: Alexa Fluor 488
• Gene Accession No.: P05019
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: IGF-I (Russel, W.E., (1984). Proc. Natl. Acad. Sci. U. S. A. 81(8):2389-2392). 40% cross reactivity to IGF-II (Van Wyk, J.J., and Bruton, E.T. (1997). Endocrinology. 138(10):4521-4522).
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG1 κ

• Applications: Immunocytochemistry
• Clone: Sm1.2
• Formulation: Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
• Gene Symbols: IGF1, IBP1
• Immunogen: Highly purified human plasma insulin-like growth factor I (IGF-I; Somatomedin C; Sm-C) conjugated to mouse albumin (Van Wyk, J.J., and Bruton, E.T. (1997). Endocrinology. 138(10):4521-4522). Action of somatomedins on cell growth: Effect of selective neutralisation of somatomedin C (IGF-I) with a Monoclonal. In: Raiti, S., Tolman, and R.A. (eds.), Human Growth Hormone. pp. 585–599. Plenum Publishing Corp., New York, NY).
• Quantity: 100 μL
• Research Discipline: Signaling
• Gene ID (Entrez): NP_000609
• Target Species: Chicken, Fish, Human, Mouse, Rat
• Form: Purified

For Research Use Only