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MilliporeSigma™ anti-IGF-I Alexa Fluor 488, Clone: Sm1.2,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ 05172AF488

Catalog No. 05-172-AF488


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Description

Description

Specifically detects IGF-I Clone: Sm1.2 in Chicken, Fish, Human, Mouse, Rat samples, and it is validated for Immunocytochemistry

Insulin-like growth factor I (UniProt P05019; also known as IGF-I, Somatomedin-C) is encoded by the IGF1 (also known as IGFI, MGF) gene (Gene ID 3479) in human. Human insulin-like growth factor-I (IGF-I) is a single chain 70 amino acid polypeptide that shares structural homology with insulin and human IGF-II. IGF-I plays a critical role in growth, differentiation and development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-I is a regulator of metabolism and is also implicated in the pathophysiology of cancer, diabetes and obesity. Upon binding the tetrameric (alpha:beta)2 IGF-I receptor, the receptor alpha chains induce the tyrosine autophosphorylation of the beta chains, which in turn trigger cell type-specific downstream signaling cascade of events.
Specifications

Specifications

IGF-I
Sm1.2
Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
Purified
Murine
IgG1, κ
100μL
Signaling
Primary
NP_000609
Chicken, Fish, Human, Murine, Rat
Immunocytochemistry
Alexa Fluor 488
P05019
IGF1, IBP1
Highly purified human plasma insulin-like growth factor I (IGF-I; Somatomedin C; Sm-C) conjugated to mouse albumin (Van Wyk, J.J., and Bruton, E.T. (1997). Endocrinology. 138(10):4521-4522). Action of somatomedins on cell growth: Effect of selective neutralisation of somatomedin C (IGF-I) with a Monoclonal. In: Raiti, S., Tolman, and R.A. (eds.), Human Growth Hormone. pp. 585–599. Plenum Publishing Corp., New York, NY).
Protein G purified
RUO
2°C to 8°C for one year from date of shipment
Monoclonal
IGF-I (Russel, W.E., (1984). Proc. Natl. Acad. Sci. U. S. A. 81(8):2389-2392). 40% cross reactivity to IGF-II (Van Wyk, J.J., and Bruton, E.T. (1997). Endocrinology. 138(10):4521-4522).
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