IGF1R alpha Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA524610
This antibody is predicted to react with mouse and rat based on sequence homology.IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of maligt cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.
|KLH conjugated synthetic peptide between 51-77 amino acids from the N-terminal region of human IGF1R|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|CD221, IGFIR, IGFR, JTK13, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2|
|-20° C, Avoid Freeze/Thaw Cycles|
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