IKAP Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14163
PA1-4163 detects IKAP in human samples. PA1-4163 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing IKAP in Interleukin-1-stimulated 293 cells. The PA1-4163 immunogen is a synthetic peptide corresponding to residues I(148) H Q D D F G E S K F I T V(161) of huamn IKAP. This sequence is 92% conserved in rat, and 85% conserved in mouse.The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes These large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for three different kinases involved in pro-inflammatory cytokine signaling.
|Synthetic peptide corresponding to residues I(148) H Q D D F G E S K F I T V(161) of huamn IKAP.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|IkappaB kinase complex-associated protein, IKK complex-associated protein, p150|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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