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IKAP Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14164

Catalog No. PA14164


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Description

Description

PA1-4164 detects IKAP in human samples. PA1-4164 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing IKAP in Interleukin-1-stimulated 293 cells. The PA1-4164 immunogen is a synthetic peptide corresponding to the C-terminus of IKAP.

The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes These large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for three different kinases involved in pro-inflammatory cytokine signaling.  
Specifications

Specifications

IKAP
Polyclonal
Unconjugated
ELP1
Liquid
ELP1
Synthetic peptide corresponding to the C-terminus of IKAP.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O95163
IkappaB kinase complex-associated protein, IKK complex-associated protein, p150
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8518
Documents
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