IKAP Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520286
A suggested positive control is A-20 cell lysate. PA5-20286 can be used with blocking peptide PEP-0404.IKAP was initially identified as a scaffold protein of the Ikappa-B kinase complex that could bind to IKK-a, IKK-b, NF-kappa-B, and the NF-kappa-B-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.
|A 16 amino acid peptide from near the carboxy terminus of human IKAP.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-3J11.4, DYS, ELP1, FD, IKAP, IKI3, TOT1; IKK complex-associated protein; elongator complex protein 1; ikappaB kinase complex-associated protein; p150|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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