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IKK beta Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA132139

Catalog No. PIPA132139


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Description

Description

PA1-32139 detects IKK beta from rat, mouse, human samples. PA1-32139 has been successfully used in ELISA, immunoprecipitation, Western blot applications. The PA1-32139 immunogen is: Synthetic peptide conjugated to KLH- which corresponds to the highly conserved C-terminus region of the human protein. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
Specifications

Specifications

IKK beta
Polyclonal
whole serum with 0.01% sodium azide
O14920, O88351, Q9QY78
FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Immunoprecipitation, Western Blot
Unconjugated
IKBKB
Liquid
IKBKB
Synthetic peptide conjugated to KLH- which corresponds to the highly conserved C-terminus region of the human protein.
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16150, 3551, 84351
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